Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/131945
Title: Wilson's disease presenting as haemolytic anaemia and its successful treatment with penicillamine and zinc
Authors: Kong, H.L. 
Yap, I.L.E. 
Kueh, Y.K. 
Keywords: cirrhosis
coagulopathy
oxidative damage
penicillamine
zinc
Issue Date: Dec-1996
Source: Kong, H.L., Yap, I.L.E., Kueh, Y.K. (1996-12). Wilson's disease presenting as haemolytic anaemia and its successful treatment with penicillamine and zinc. Singapore Medical Journal 37 (6) : 670-672. ScholarBank@NUS Repository.
Abstract: Haemolysis is an uncommon first manifestation of Wilson's disease. We describe a young woman who presented with episodic haemolysis and abnormal liver functions; the diagnosis of Wilson's disease was not made until nine months later. She responded well to a combination of penicillamine and zinc. This report underscores the importance of considering Wilson's disease as a cause in a patient with haemolysis of uncertain aetiology, since the disease can be successfully treated in the early stages. The mechanism of oxidative damage to erythrocytes by the excessive copper and the present role of zinc therapy are also discussed.
Source Title: Singapore Medical Journal
URI: http://scholarbank.nus.edu.sg/handle/10635/131945
ISSN: 00375675
Appears in Collections:Staff Publications

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