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|Title:||Vincristine therapy in refractory chronic idiopathic thrombocytopenic purpura|
|Source:||Kueh, Y.K. (1982). Vincristine therapy in refractory chronic idiopathic thrombocytopenic purpura. Annals of the Academy of Medicine Singapore 11 (2) : 290-293. ScholarBank@NUS Repository.|
|Abstract:||12 patients with refractory, chronic idiopathic thrombocytopenic purpura, (ITP) received weekly (1 mg) vincristine injections to a cumulative dose not greater than 3 mg. No complications were encountered. 8 patients (67%) showed a rise in the platelet count following the first injections. 5 out of the 8 patients achieved a normal platelet count (>150 x 109/l) after the second dose of vincristine, while 3 obtained variable platelet rises of 20 to 110 x 109/l above the pre-treatment levels. The duration of platelet response to vincristine without concomitant azathioprine therapy was less then 10 weeks. The simultaneous administration of vincristine and azathioprine resulted in a sustained response in 5 patients.|
|Source Title:||Annals of the Academy of Medicine Singapore|
|Appears in Collections:||Staff Publications|
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