Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/131896
Title: Ultrastructural changes in the gracile nucleus of alloxan-induced diabetic rats
Authors: Tay, S.S.W. 
Wong, W.C.
Issue Date: 1990
Source: Tay, S.S.W., Wong, W.C. (1990). Ultrastructural changes in the gracile nucleus of alloxan-induced diabetic rats. Acta Anatomica 139 (4) : 367-373. ScholarBank@NUS Repository.
Abstract: The present study reports ultrastructural changes in the gracile nucleus of male Wistar rats after alloxan-induced diabetes. During the acute phase (3-7 days) degenerating electron-dense dendrites and axon terminals were dispersed in the neuropil. Degenerating dendrites were characterized by an electron-dense cytoplasm, swollen mitochondria, dilated endoplasmic reticulum and randomized ribosomes. Degenerating axon terminals were characterized by an electron-dense cytoplasm and clustering of small spherical agranular vesicles. Degenerating axon terminals may form the central element or part of a synaptic glomerulus. Macrophages were present in the neuropil and in the process of engulfing neuronal elements. During the medium phase (1-6 months), most of the degenerating dendrites and axon terminals had been engulfed or removed by macrophages. During the late phase (9-12 months), a second wave of degeneration occurred in the gracile nucleus, similar to the acute phase.
Source Title: Acta Anatomica
URI: http://scholarbank.nus.edu.sg/handle/10635/131896
ISSN: 00015180
Appears in Collections:Staff Publications

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