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|Title:||Proton-dependent antiporter exchange: Li+ versus Na+|
|Authors:||Sit, K.H. |
|Source:||Sit, K.H., Bay, B.H., Wong, K.P. (1992). Proton-dependent antiporter exchange: Li+ versus Na+. Lithium 3 (2) : 109-115. ScholarBank@NUS Repository.|
|Abstract:||Raising extracellular pH (pH(o)) in the presence of [Li+](o) produces (i) higher intracellular pH (pH(i)) upshifts than in the presence of [Na+](o), and (ii) greater cell retraction and rounding responses, despite the fact that H+/Li+ exchanges are generally seen to be less efficient than H+/Na+ exchanges when mediated via Na+ and Li+ variations, i.e., in Na+- and Li+-dependent antiporter exchanges. Proton-downgradient dependent (PD) H+/Li+ exchanges and associated cell rounding responses are sensitive to amiloride, a Na+/H+ antiporter and Na+-channel blocker, and to saxitoxin, a Na+-channel blocker, as seen in pH(i) measurements and antiporter mediated cell retraction and rounding responses. Ultrastructural details of the retracted cell mediated by PD H+/Li+ exchanges show endosomal structures and endoplasmic reticulum swelling similar to those seen in antiporter responses mediated in the presence of [Na+](o). The observed divergence in antiporter efficiency with respect to Li+ could suggest the possibility of pleiotropic conformations in either the transporter or a modifier site when activated differently.|
|Appears in Collections:||Staff Publications|
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