Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/13183
Title: Multifunctional folate conjugated polymeric micelles for active intracellular drug delivery
Authors: ZHAO HAIZHENG
Keywords: Folate, Polymer micelles, Targeting, PLGA, Drug delivery, Doxorubicin
Issue Date: 17-Apr-2008
Source: ZHAO HAIZHENG (2008-04-17). Multifunctional folate conjugated polymeric micelles for active intracellular drug delivery. ScholarBank@NUS Repository.
Abstract: In this thesis, folate was employed as a targeting moiety of anticancer agents to increase their cellular uptake within cancer cells. A folate conjugated polymer- PLGA-PEG-FOL was used to form micelles for encapsulating doxorubicin. The difference of cytotoxicity, cellular uptake and apoptosis percentage between cancer cells and healthy cells implies that the folate conjugated micelles has the ability to selectively target cancer cells.To overcome the development of multidrug-resistant during cancer treatment, a new drug formulation - PLGA-PEG-FOL formulated with d-N1-tocopheryl polyethylene glycol succinate (TPGS) was fabricated. Compared with the PLGA-PEG-FOL formulation, the addition of TPGS showed higher drug cellular uptake and higher cytotoxicity to drug resistant cells. In addition, the formulations with TPGS also selectively enhance the cytotoxicity of drug resistant cancer cells with overexpressed folate receptors and affect normal cells at minimum. The pharmacokinetics and biodistribution of this new formulation was also evaluated with rat tumor xenograft models.
URI: http://scholarbank.nus.edu.sg/handle/10635/13183
Appears in Collections:Ph.D Theses (Open)

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