Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1365-2982.2005.00627.x
Title: Irritable bowel syndrome in developing countries - A disorder of civilization or colonization?
Authors: Gwee, K.-A. 
Keywords: Asia
Epidemiology
Gender
Hygiene hypothesis
Pathogenesis
Symptoms
Issue Date: Jun-2005
Citation: Gwee, K.-A. (2005-06). Irritable bowel syndrome in developing countries - A disorder of civilization or colonization?. Neurogastroenterology and Motility 17 (3) : 317-324. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1365-2982.2005.00627.x
Abstract: While irritable bowel syndrome (IBS) is common in the West, early studies suggest that the prevalence is low in developing countries. However, recent studies point to increasing prevalence in newly developed Asian economies. The presentation appears to differ from the West, with a lack of female predominance, a greater frequency of upper abdominal pain and defecatory symptoms perceived as being less bothersome. This difference, together with the preoccupation with organic disease, could explain why we may be missing IBS in Asia and also why excess surgery has been observed in some Asian countries. While a recent study from China, consistent with western studies, support an important role for infection and inflammation, early studies from India reporting no association between amoebic infection and IBS appear to dispute this observation. To reconcile these seemingly contradictory observations, an hygiene hypothesis model is proposed. Exposure to a variety of microorganisms early in life could result in the colonization of the intestine with microflora that can respond more efficiently to an episode of gastroenteritis. Together with the changes with evolution of Asian economies such as westernization of the diet and increased psychosocial stress, it is proposed that loss of this internal protective effect, could give rise to a more uniform worldwide prevalence of IBS. © 2005 Blackwell Publishing Ltd.
Source Title: Neurogastroenterology and Motility
URI: http://scholarbank.nus.edu.sg/handle/10635/131816
ISSN: 13501925
DOI: 10.1111/j.1365-2982.2005.00627.x
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

132
checked on Sep 11, 2018

WEB OF SCIENCETM
Citations

117
checked on Sep 11, 2018

Page view(s)

16
checked on Aug 16, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.