Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/13180
Title: The composition of early life gut microbiota in relation to geographical origins, probiotic use and childhood eczema
Authors: MAH KA WENG
Keywords: Gut microbiota, atopy, eczema, probiotics, allergy
Issue Date: 23-May-2008
Source: MAH KA WENG (2008-05-23). The composition of early life gut microbiota in relation to geographical origins, probiotic use and childhood eczema. ScholarBank@NUS Repository.
Abstract: It has been suggested that bacteria residing in the neonatal gut influences the hostb s developmental processes and exerts lasting immunological effects on disease states later in life. The composition of gut microbiota in children with and without eczema was compared. Eczematous children harbored increased enterococcal counts but lower counts of bifidobacteria and commensal clostridia. Furthermore, the gut microbiota of children from two South East Asian regions with contrasting socioeconomic status was also studied. Significantly higher numbers of certain microbes were found in children from rural Thai compared to urban Singapore. Using more powerful molecular technologies, it was subsequently found that the colonization of major bacterial phylotypes was not influenced by probiotic administration from birth. PCR detection revealed that these probiotic strains were found in the feces of subjects, only during the period of supplementation.This interesting field of study may offer innovative dimensions to future paediatric research.
URI: http://scholarbank.nus.edu.sg/handle/10635/13180
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