Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/13176
Title: A study of factors affecting spray-congealed micropellets for drug delivery
Authors: GUO QIYUN
Keywords: spray congealing, size and size distribution, drug release, hydrogenated soybean oil, polyethylene glycol, aspirin
Issue Date: 21-Apr-2008
Source: GUO QIYUN (2008-04-21). A study of factors affecting spray-congealed micropellets for drug delivery. ScholarBank@NUS Repository.
Abstract: Microencapsulation of drug by spray congealing is relatively new. Hypothetically, a mixture of drug and molten matrix material could be atomised in a cooling chamber to form micropellets with the desired properties for various applications. Hence, this study was carried out to investigate the influence of various process and formulation parameters on the properties of spray-congealed products. Generally, spherical and discrete micropellets could be produced from either pure hydrogenated soybean oil (HSO) or polyethylene glycol (PEG). The atomising air flow rate and spray feed rate were the primary determinants of the micropellet size. In contrast to PEG, formation of HSO micropellets with sustained release of aspirin could be achieved. The increase in drug load, drug particle size and surfactant concentration, as well as compression of the micropellets enhanced drug release by different mechanisms. The stability of aspirin was also markedly improved by the protective function of the hydrophobic HSO.
URI: http://scholarbank.nus.edu.sg/handle/10635/13176
Appears in Collections:Ph.D Theses (Open)

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01 Title page.pdf7.41 kBAdobe PDF

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02 Acknowledgement.pdf8.31 kBAdobe PDF

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03 Table of contents.pdf16.81 kBAdobe PDF

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04 Summary.pdf63.84 kBAdobe PDF

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05 List of tables.pdf9.79 kBAdobe PDF

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06 List of figures.pdf72.61 kBAdobe PDF

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07 Introduction.pdf137.29 kBAdobe PDF

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08 Objective.pdf13.21 kBAdobe PDF

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09 Experimental.pdf113.28 kBAdobe PDF

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10 Results & Discussion.pdf3.66 MBAdobe PDF

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11 Conclusion.pdf66.16 kBAdobe PDF

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12 References.pdf95.75 kBAdobe PDF

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13 Appendices.pdf50.02 kBAdobe PDF

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14 Publications.pdf10.15 kBAdobe PDF

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