Please use this identifier to cite or link to this item:
|Title:||Polymeric micelles anchored with TAT for delivery of antibiotics across the blood-brain barrier|
|Source:||Liu, L., Venkatraman, S.S., Yang, Y.-Y., Guo, K., Lu, J., He, B., Moochhala, S., Kan, L. (2008). Polymeric micelles anchored with TAT for delivery of antibiotics across the blood-brain barrier. Biopolymers - Peptide Science Section 90 (5) : 617-623. ScholarBank@NUS Repository. https://doi.org/10.1002/bip.20998|
|Abstract:||Polymeric micelles self-assembled from cholesterol-conjugated poly(ethylene glycol) (PEG) and anchored with transcriptional activator TAT peptide (TAT-PEG-b-Col) were fabricated for delivery of antibiotics across the blood-brain barrier (BBB). Ciprofloxacin, which demonstrated a high bactericidal effect, was efficiently loaded into the micelles by a membrane dialysis method. The ciprofloxacin-loaded micelles were characterized via dynamic light scattering and SEM. The micelles were spherical in nature, having an average diameter of smaller than 180 nm. Sustained release of ciprofloxacin was achieved over 6 h in phosphate-buffered saline (pH 7.4) at 37°C. Confocal laser scanning microscopy reveals that the uptake of Fluorescein 5-isothiocyanate (FITC)-loaded TAT-PEG-b-Col micelles by human astrocytes was much higher than that of free FITC. Animal studies proved that these micelles crossed the BBB and entered the brain. The TAT-conjugated micelles may be used to deliver antibiotics across the BBB for treatment of brain infections. © 2008 Wiley Periodicals, Inc.|
|Source Title:||Biopolymers - Peptide Science Section|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 17, 2018
WEB OF SCIENCETM
checked on Jan 2, 2018
checked on Jan 14, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.