Please use this identifier to cite or link to this item: https://doi.org/10.1136/gut.2004.062034
Title: Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: A randomised, double blind, placebo controlled study
Authors: Song, G.H. 
Leng, P.H.
Gwee, K.A. 
Moochhala, S.M. 
Ho, K.Y.
Issue Date: Oct-2005
Source: Song, G.H., Leng, P.H., Gwee, K.A., Moochhala, S.M., Ho, K.Y. (2005-10). Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: A randomised, double blind, placebo controlled study. Gut 54 (10) : 1402-1407. ScholarBank@NUS Repository. https://doi.org/10.1136/gut.2004.062034
Abstract: Background and aims: Melatonin, a sleep promoting agent, is involved in the regulation of gastrointestinal motility and sensation. We aimed to determine if melatonin was effective in improving bowel symptoms and sleep disturbances in irritable bowel syndrome (IBS) patients with sleep disturbance. Methods: Forty IBS patients (aged 20-64 years; 24 female) with sleep disturbances were randomly assigned to receive either melatonin 3 mg (n = 20) or matching placebo (n = 20) at bedtime for two weeks. Immediately before and after the treatment, subjects completed bowel, sleep, and psychological questionnaires, and underwent rectal manometry and overnight polysomnography. Results: Compared with placebo, melatonin taken for two weeks significantly decreased mean abdominal pain score (2.35 v 0.70; p
Source Title: Gut
URI: http://scholarbank.nus.edu.sg/handle/10635/131540
ISSN: 00175749
DOI: 10.1136/gut.2004.062034
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