Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/131537
DC Field | Value | |
---|---|---|
dc.title | Interleukin-18 promoter gene polymorphisms in Chinese patients with systemic lupus erythematosus: Association with CC genotype at position -607 | |
dc.contributor.author | Xu, Q. | |
dc.contributor.author | Soe, K.T. | |
dc.contributor.author | Paramalingam, S.S. | |
dc.contributor.author | Thumboo, J. | |
dc.contributor.author | Koh, D.-R. | |
dc.contributor.author | Fong, K.-Y. | |
dc.date.accessioned | 2016-11-29T01:19:48Z | |
dc.date.available | 2016-11-29T01:19:48Z | |
dc.date.issued | 2007-02 | |
dc.identifier.citation | Xu, Q., Soe, K.T., Paramalingam, S.S., Thumboo, J., Koh, D.-R., Fong, K.-Y. (2007-02). Interleukin-18 promoter gene polymorphisms in Chinese patients with systemic lupus erythematosus: Association with CC genotype at position -607. Annals of the Academy of Medicine Singapore 36 (2) : 91-95. ScholarBank@NUS Repository. | |
dc.identifier.issn | 03044602 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/131537 | |
dc.description.abstract | Introduction: Interleukin-18 (IL-18) is a Th1 cytokine, which is postulated to play a role in systemic lupus erythematosus (SLE). Two single nucleotide polymorphisms (SNPs) in the IL-18 promoter gene region were found to influence the quantitative expression of the IL-18 protein. The aim of this study was to determine whether IL-18 promoter gene polymorphisms are associated with SLE. Materials and Methods: One hundred and thirteen Chinese SLE patients and 218 Chinese healthy individuals were recruited. Genomic DNA was extracted from peripheral venous blood. Sequence-specific primer PCR and restriction fragment length polymorphism (RFLP) analysis were used to genotype the DNA samples for SNP-137 and SNP-607. The following genotypes were obtained: SNP(-607) AA, AC, CC and SNP(-137) GG, GC, CC. Plasma IL-18 concentrations of patients and control subjects were measured by enzyme-linked immunosorbent assay. Results: the frequency of SNP-607/CC genotype was significantly higher in SLE patients (Pc < 0.05) while genotype SNP-607/AC was significantly decreased in SLE patients compared to the control group (Pc | |
dc.source | Scopus | |
dc.subject | Cytokines | |
dc.subject | Genotype | |
dc.subject | Single nucleotide polymorphisms | |
dc.type | Article | |
dc.contributor.department | MEDICINE | |
dc.description.sourcetitle | Annals of the Academy of Medicine Singapore | |
dc.description.volume | 36 | |
dc.description.issue | 2 | |
dc.description.page | 91-95 | |
dc.description.coden | AAMSC | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
Show simple item record
Files in This Item:
There are no files associated with this item.
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.