Please use this identifier to cite or link to this item:
|Title:||Polycomb group complexes self-regulate imprinting of the polycomb group gene MEDEA in Arabidopsis|
|Source:||Jullien, P.E., Katz, A., Oliva, M., Ohad, N., Berger, F. (2006-03-07). Polycomb group complexes self-regulate imprinting of the polycomb group gene MEDEA in Arabidopsis. Current Biology 16 (5) : 486-492. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cub.2006.01.020|
|Abstract:||Fertilization in flowering plants initiates the development of the embryo and endosperm, which nurtures the embryo. A few genes subjected to imprinting are expressed in endosperm from their maternal allele, while their paternal allele remains silenced [1-3]. Imprinting of the FWA gene involves DNA methylation . Mechanisms controlling imprinting of the Polycomb group (Pc-G) gene MEDEA (MEA)  are not yet fully understood [6-10]. Here we report that MEA imprinting is regulated by histone methylation. This epigenetic chromatin modification is mediated by several Pc-G activities during the entire plant life cycle. We show that Pc-G complexes maintain MEA transcription silenced throughout vegetative life and male gametogenesis. In endosperm, the maternal allele of MEA encodes an essential component of a Pc-G complex, which maintains silencing of the paternal MEA allele. Hence, we conclude that a feedback loop controls MEA imprinting. This feedback loop ensures a complete maternal control of MEA expression from both parental alleles and might have provided a template for evolution of imprinting in plants. ©2006 Elsevier Ltd All rights reserved.|
|Source Title:||Current Biology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 24, 2018
WEB OF SCIENCETM
checked on Nov 22, 2017
checked on Jan 21, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.