Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/131365
Title: Mass newborn screening for glucose-6-phosphate dehydrogenase deficiency in Singapore
Authors: Joseph, R.
Ho, L.Y.
Gomez, J.M.
Rajdurai, V.S.
Sivasankaran, S. 
Yip, Y.Y. 
Issue Date: 1999
Source: Joseph, R., Ho, L.Y., Gomez, J.M., Rajdurai, V.S., Sivasankaran, S., Yip, Y.Y. (1999). Mass newborn screening for glucose-6-phosphate dehydrogenase deficiency in Singapore. Southeast Asian Journal of Tropical Medicine and Public Health 30 (SUPPL. 2) : 70-71. ScholarBank@NUS Repository.
Abstract: Recognition of kernicterus as a significant contributor to newborn mortality and morbidity in G6PD deficient babies and the ease with which G6PD deficiency could be detected and kernicterus prevented by avoidance of triggers, led to the establishment of mass newborn screening for G6PD deficiency in 1965. G6PD deficient newborns are identified within a day of birth by measuring the enzyme activity in cord blood. They are then physically protected from triggers by keeping them in the hospital for the first 2 weeks of life after their parents are counseled. Enzyme activity is measured using Wong's in-house modification of the Bernstein's technique or the BM G6PD Deficiency Screening test based on the Beutler assay. Close to 1.6 million newborns, representing practically 100% of all births have been screened. Analysis of data from 22,830 newboms at the National University Hospital reveals an incidence of 1.62% in all newborns, 3.15% in males and and 0.11% in females. A distinct racial variation in the incidence of deficiency was observed in males : Chinese 3.94%, Malays 2.95% and Indians 0.66%. Intermediate deficiency was most frequently identified (1.83%) in Chinese females. With the preventive measures, the incidence of kernicterus has dropped dramatically and there has been, over the last 20 years, no reported cases of kernicterus in newborns with G6PD deficiency. We are now looking at issues like comparing different assay techniques and determining a shorter period of stay in hospital. We believe that all Asians, especially Chinese babies, should be screened for G6PD deficiency, irrespective of which country the child is born.
Source Title: Southeast Asian Journal of Tropical Medicine and Public Health
URI: http://scholarbank.nus.edu.sg/handle/10635/131365
ISSN: 01251562
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

9
checked on Jan 20, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.