Please use this identifier to cite or link to this item: https://doi.org/10.1515/JPM.2004.023
Title: Oxytocic activity of thrombin: Modulation of thrombin-induced gravid rat myometrial contractions by 5-hydroxytryptamine receptor antagonists
Authors: Adebiyi, A.
Adaikan, G.P. 
Prasad, R.N.V. 
Keywords: 5-hydroxytryptamine
Ketanserin
Methysergide
Myometrial contractions
Oxytocic activity
Thrombin
Issue Date: 2004
Citation: Adebiyi, A., Adaikan, G.P., Prasad, R.N.V. (2004). Oxytocic activity of thrombin: Modulation of thrombin-induced gravid rat myometrial contractions by 5-hydroxytryptamine receptor antagonists. Journal of Perinatal Medicine 32 (2) : 126-131. ScholarBank@NUS Repository. https://doi.org/10.1515/JPM.2004.023
Abstract: Background: Thrombin possesses potent oxytocic activity in vitro and in vivo. This activity has been proposed to play a role in post-parturitional uterine contractions and possibly, preterm birth related to intrauterine hemorrhage. Previous workers have demonstrated that cyclo-oxygenase pathway may not play a significant role in oxytocic activity of thrombin. However, the role of 5-hydroxytryptamine (a mediator of some of the biological activities of thrombin) in the oxytocic activity of thrombin is unknown. The present study therefore aimed to examine the possible involvement of 5-hydroxytryptamine in thrombin-induced myometrial contractions. Methods: Effect of 5-hydroxytryptamine receptor antagonists on thrombin-induced contractions of isolated gravid rat myometrium was studied using isolated tissue bath system. Results: Thrombin-induced myometrial contractions were significantly and concentration-dependently inhibited by ketanserin and methysergide. Furthermore, 12±2% increase in the force of contractions of gravid rat myometrium pre-contracted with 5-hydroxytryptamine (1 μM) was provoked by 1 U/ml of thrombin. Thrombin-induced augmentation of the uterine stimulating effect of 5-hydroxytryptamine was characterized by pronounced increase in the contractile tone. Conclusions: 5-hydroxytryptamine may possibly play a role in oxytocic activity of thrombin. Uterine hyperactivity associated with intrauterine hemorrhage could hence involve thrombin-induced 5-hydroxytryptamine production in the uterus.
Source Title: Journal of Perinatal Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/131330
ISSN: 03005577
DOI: 10.1515/JPM.2004.023
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

2
checked on Sep 19, 2018

WEB OF SCIENCETM
Citations

1
checked on Sep 19, 2018

Page view(s)

16
checked on Jul 5, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.