Please use this identifier to cite or link to this item: https://doi.org/10.1078/0944-7113-00287
Title: Histaminergic effect of crude papaya latex on isolated guinea pig ileal strips
Authors: Adebiyi, A.
Adaikan, P.G. 
Prasad, R.N.V. 
Keywords: Contraction
Crude papaya latex
Extracellular Ca 2+
H 1-receptors
Histaminergic
Ileal strips
Issue Date: Jan-2004
Source: Adebiyi, A., Adaikan, P.G., Prasad, R.N.V. (2004-01). Histaminergic effect of crude papaya latex on isolated guinea pig ileal strips. Phytomedicine 11 (1) : 65-70. ScholarBank@NUS Repository. https://doi.org/10.1078/0944-7113-00287
Abstract: In the present study, we investigated the effect of the crude latex of Carica papaya L. (CPX) on isolated guinea pig ileal strips. CPX (0.5-512 μg/ml) caused concentration-dependent contraction of ileal strips suspended in Tyrode solution. The concentration of atropine (0.69 μM) that significantly blocked the contractile effect of acetylcholine on the isolated guinea pig ileum showed no significant effect on CPX- and histamine-induced contractions of the ileal strips. Mepyramine (87.6 nM) significantly blocked the contractile effect of histamine and CPX on the ileum. The same concentration of mepyramine, however, had no significant effect on acetylcholine-induced contraction of the isolated ileal strips. Removal of Ca 2+ from the bathing medium abolished ileal contractions induced by acetylcholine, histamine and CPX. All the test substances were able to provoke ileal contractions after replacement of the Ca 2+-free solution with Tyrode solution. Furthermore, 10 -5 M of nifedipine, a Ca 2+-entry antagonist, reversibly inhibited the contractile effect of all the test substances on the ileal strips. Results of this study together appear to show that CPX-induced contraction of the isolated guinea pig ileum is mediated via H 1-receptors and dependent on extracellular Ca 2+ influx.
Source Title: Phytomedicine
URI: http://scholarbank.nus.edu.sg/handle/10635/131300
ISSN: 09447113
DOI: 10.1078/0944-7113-00287
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

6
checked on Jan 16, 2018

WEB OF SCIENCETM
Citations

2
checked on Nov 22, 2017

Page view(s)

8
checked on Jan 20, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.