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https://doi.org/10.1016/0198-8859(95)00085-2
Title: | Influence of gender and age at onset on the HLA associations in Chinese with insulin-dependent diabetes mellitus | Authors: | Chan, S.H. Thai, A.C. Lin, Y.N. Liu, K.F. Wee, G.B. |
Issue Date: | 1995 | Citation: | Chan, S.H., Thai, A.C., Lin, Y.N., Liu, K.F., Wee, G.B. (1995). Influence of gender and age at onset on the HLA associations in Chinese with insulin-dependent diabetes mellitus. Human Immunology 44 (3) : 175-180. ScholarBank@NUS Repository. https://doi.org/10.1016/0198-8859(95)00085-2 | Abstract: | IDDM in Singaporean Chinese was associated with HLA B58, DRB1*0301, DQB1*0201, and joint occurrences of DRB1*0301/*0901 and DRB1*0301/*04. Of the DR4s the frequencies of DRB1*0401, *0404, and *0405 were higher and *0406 was lower in patients compared to controls. DRB*0301/*0901 was observed mainly in female patients and the frequency showed an inverse relationship with age at onset, whereas DRB1*0301/*04 was observed mainly in male patients and also showed an inverse relationship with age at onset. DRB1*1202 showed an increasing frequency with age at onset. IDDM patients had a higher frequency of homozygous NAsp57 DQβ chains and a lower frequency of homozygous Asp57 DQβ chains compared to controls, especially in younger onset patients. | Source Title: | Human Immunology | URI: | http://scholarbank.nus.edu.sg/handle/10635/131283 | ISSN: | 01988859 | DOI: | 10.1016/0198-8859(95)00085-2 |
Appears in Collections: | Staff Publications |
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