Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/13126
Title: Telomere-chromosome integrity in breast cancer
Authors: ANURADHA POONEPALLI
Keywords: Telomeres, Breast cancer, BRCA1, genomic instability, Prognostic markers
Issue Date: 22-May-2008
Source: ANURADHA POONEPALLI (2008-05-22). Telomere-chromosome integrity in breast cancer. ScholarBank@NUS Repository.
Abstract: Telomere mediated instability promotes tumorigenesis. A number of DNA repair proteins are increasingly discovered to play a role in telomere integrity. BRCA1 has been shown to interact with proteins like ATM, Rad50, MRN complex which have a role in telomere maintenance. Brca1-/- T cells derived from Brca1 conditional knockout mice under either p53-/- or Bcl2 background displayed telomere shortening and dysfunction. Furthermore, BRCA1 showed recruitment at chromosomal ends and partial colocalisation with TRF2. Breast cancer was chosen as a model to explore the association between telomere-homeostasis and tumor progression. Significantly greater telomere shortening and associated dysfunction was observed in higher grade breast tumors (p<0.05).The higher grade tumors were also associated with greater genomic imbalances as revealed by array-CGH. Telomere attrition in the higher grades was also associated with increased telomerase activity, decreased expression of negative regulators like TRF1 and POT1 and increased expression of positive regulator Tankyrase 1.
URI: http://scholarbank.nus.edu.sg/handle/10635/13126
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