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|Title:||Inhibition of staphylococcal enterotoxin-driven lymphocyte proliferation by anti-MHC class II monoclonal antibody|
|Citation:||Loh, M.-T., Srinivasan, N., Chan, S.-H., Ren, E.-C. (1995). Inhibition of staphylococcal enterotoxin-driven lymphocyte proliferation by anti-MHC class II monoclonal antibody. Hybridoma 14 (5) : 429-433. ScholarBank@NUS Repository.|
|Abstract:||Staphylococcal enterotoxins (SE) bind to major histocompatibility complex (MHC) class II molecules and the Vβ region of T cell receptors (TCR) and subsequently induces T cell proliferation. This mitogenicity is the basis of pathological effects seen in food poisoning and toxic shock syndrome. Toxin- specific monoclonal antibodies have previously been shown to be effective in blocking toxin stimulated T cell responses. In this study, a monoclonal antibody, 52BL1, was found to be a potent inhibitor of SEA-, SEB-, SEC1-, SED-, and SEE-induced lymphocyte proliferation assays, which indicates that a single anti-HLA (human leukocyte antigen) class II antibody is effective in blocking the biological effects of these toxins. These results demonstrate the possibility of using anti-HLA class II antibodies in a clinical setting as an antagonist to staphylococcal enterotoxin-mediated pathogenesis.|
|Appears in Collections:||Staff Publications|
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