Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/131254
Title: Inhibition of staphylococcal enterotoxin-driven lymphocyte proliferation by anti-MHC class II monoclonal antibody
Authors: Loh, M.-T.
Srinivasan, N.
Chan, S.-H. 
Ren, E.-C. 
Issue Date: 1995
Citation: Loh, M.-T., Srinivasan, N., Chan, S.-H., Ren, E.-C. (1995). Inhibition of staphylococcal enterotoxin-driven lymphocyte proliferation by anti-MHC class II monoclonal antibody. Hybridoma 14 (5) : 429-433. ScholarBank@NUS Repository.
Abstract: Staphylococcal enterotoxins (SE) bind to major histocompatibility complex (MHC) class II molecules and the Vβ region of T cell receptors (TCR) and subsequently induces T cell proliferation. This mitogenicity is the basis of pathological effects seen in food poisoning and toxic shock syndrome. Toxin- specific monoclonal antibodies have previously been shown to be effective in blocking toxin stimulated T cell responses. In this study, a monoclonal antibody, 52BL1, was found to be a potent inhibitor of SEA-, SEB-, SEC1-, SED-, and SEE-induced lymphocyte proliferation assays, which indicates that a single anti-HLA (human leukocyte antigen) class II antibody is effective in blocking the biological effects of these toxins. These results demonstrate the possibility of using anti-HLA class II antibodies in a clinical setting as an antagonist to staphylococcal enterotoxin-mediated pathogenesis.
Source Title: Hybridoma
URI: http://scholarbank.nus.edu.sg/handle/10635/131254
ISSN: 0272457X
Appears in Collections:Staff Publications

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