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|Title:||Pharmacokinetics of oral salbutamol controlled-release in Asian patients with asthma|
|Authors:||Tan, W.C. |
|Citation:||Tan, W.C., Lee, H.S. (1991). Pharmacokinetics of oral salbutamol controlled-release in Asian patients with asthma. European Journal of Clinical Pharmacology 41 (5) : 495-496. ScholarBank@NUS Repository.|
|Abstract:||Using a double blind, double dummy crossover design, single dose and steady state pharmacokinetics of oral controlled release (SCR) salbutamol 4 mg and 8 mg tablets b.d. has been studied in 8 Asian patients. Plasma salbutamol was measured over 12 h. In 8 patients the single dose mean C(max) was 4.2 ng · ml-1 and 7.7 ng · ml-1 after 4 and 8 mg, respectively. In 5 patients the steady state mean C(max), C(min) and t(max) were S.1 ng · ml-1 and 4.7 ng · ml-1 and 6 h for the 4 mg tablets and 14.1 ng · ml-1 and 7.1 ng · ml-1 and 4 h for the 8 mg tablets. It is concluded that both doses of SCR show features of controlled release and that they produced a relatively constant plasma level of salbutamol in Asian patients.|
|Source Title:||European Journal of Clinical Pharmacology|
|Appears in Collections:||Staff Publications|
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