Please use this identifier to cite or link to this item:
https://doi.org/10.1111/j.1444-0903.2004.00482.x
DC Field | Value | |
---|---|---|
dc.title | Low prevalence of autoimmune diabetes markers in a mixed ethnic population of Singaporean diabetics | |
dc.contributor.author | Todd, A.L. | |
dc.contributor.author | Ng, W.Y. | |
dc.contributor.author | Lui, K.F. | |
dc.contributor.author | Thai, A.C. | |
dc.date.accessioned | 2016-11-28T10:17:28Z | |
dc.date.available | 2016-11-28T10:17:28Z | |
dc.date.issued | 2004-01 | |
dc.identifier.citation | Todd, A.L., Ng, W.Y., Lui, K.F., Thai, A.C. (2004-01). Low prevalence of autoimmune diabetes markers in a mixed ethnic population of Singaporean diabetics. Internal Medicine Journal 34 (1-2) : 24-30. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1444-0903.2004.00482.x | |
dc.identifier.issn | 14440903 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/131207 | |
dc.description.abstract | Background: Circulating antibodies to glutamic acid decarboxylase (GADab) and tyrosine phosphatase-like molecule IA-2 (IA-2ab) are major indicators for autoimmune destruction of pancreatic islet cells. They identify a majority of Caucasians with type 1 diabetes and approximately 50% of Asians, providing evidence of an idiopathic aetiology in the latter. The present study investigated these autoantibodies in a mixed ethnic group. Methods: Hospital clinic patients with clinically defined type 1 (n - 93) and type 2 (n = 300) diabetes and representing Singapore's major ethnic groups - Chinese, Indians and Malays - were studied. GADab and IA-2ab frequencies, and association of autoimmunity status with clinical and biochemical profiles were analysed. Results: Radio-immunoprecipitation assays detected either or both antibodies (seropositivity) in 41.9% of subjects with type 1 diabetes. GADab was detected in 36.6% and IA-2ab in 23.7% of type 1 diabetics. Prevalence of IA-2ab showed a reduction in frequency with disease duration (P = 0.026). In clinical type 2 diabetics, seropositivity was 10.0% with higher frequency in Malays (17.5%) than Chinese (9.7%) and Indians (4.5%). Multivariate analysis revealed that low fasting C-peptide was associated with seropositivity (odds ratio (OR) = 0.15; 95% confidence interval (CI) = 0.04-0.58). A significant relationship (OR= 13. 5; 95% CI = 5.0-36.7) between insulin requirement and duration (>5 years) was also revealed. In patients with type 2 diabetes there was a trend of gradual progression to insulin dependency. However, there was considerable variation in body mass index between ethnic subgroups of type 2 diabetics, particularly for Chinese (mean (SD) = 26.0 (4.7)) and Malays (mean (SD) = 29.2 (5.9); P < 0.001). Conclusions: Presence of both antibodies in our mixed ethnic group of type 1 diabetes patients was much lower than in Caucasians. Significant numbers of patients were seronegative for antibodies. Influences due to ethnicity and adiposity would require further investigations. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1111/j.1444-0903.2004.00482.x | |
dc.source | Scopus | |
dc.subject | Diabetes | |
dc.subject | Ethnicity | |
dc.subject | GaD65 antibodies | |
dc.subject | IA-2 antibodies | |
dc.subject | LADA | |
dc.type | Article | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.1111/j.1444-0903.2004.00482.x | |
dc.description.sourcetitle | Internal Medicine Journal | |
dc.description.volume | 34 | |
dc.description.issue | 1-2 | |
dc.description.page | 24-30 | |
dc.description.coden | IMJNA | |
dc.identifier.isiut | 000188541200006 | |
Appears in Collections: | Staff Publications |
Show simple item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.