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|Title:||Human genome - From pieces to patterns|
Exon-Intron Length Patterns
|Citation:||Sakharkar, M.K., Kangueane, P., Perumal, B.S., Chow, V.T.K., Sorscher, E., Sakharkar, K.R., Hill, A. (2005). Human genome - From pieces to patterns. Frontiers in Bioscience 10 (SUPPL. 2) : 2576-2584. ScholarBank@NUS Repository.|
|Abstract:||A profile of exon-intron lengths in genes shows a normal distribution. This observation suggests that different genes may have portions of their total exon and/or intron lengths in common. In order to explore the common exon-intron structural patterns that may arise due to common lengths across genes, we compared the exon-intron length patterns of annotated human genes. We discovered 1762278 conserved arrangements of exon-intron length across the otherwise unrelated and diverse genomic landscape. The existence of common exon-intron length patterns across unrelated genes suggests for their role of in gene assemblage and human genome design and architecture.|
|Source Title:||Frontiers in Bioscience|
|Appears in Collections:||Staff Publications|
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