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|Title:||Modulation of parvalbumin expression in the motor cortex of parkinsonian rats|
|Source:||Capper-Loup, C., Burgunder, J.-M., Kaelin-Lang, A. (2005-05). Modulation of parvalbumin expression in the motor cortex of parkinsonian rats. Experimental Neurology 193 (1) : 234-237. ScholarBank@NUS Repository. https://doi.org/10.1016/j.expneurol.2004.12.007|
|Abstract:||Dopamine deficiency in Parkinson's disease leads to numerous molecular changes in basal ganglia. However, the consequences of these changes on the motor cortex remain unclear. Here we show that the immunoreactivity of parvalbumin, which is expressed in GABAergic interneurons, increases in the primary motor cortex of parkinsonian rats. This increase can be reversed by a subsequent lesion of the subthalamic nucleus. These results suggest that dopamine deficiency induces reversible changes in GABAergic cortical cells, which might be linked with parkinsonian symptoms. © 2004 Elsevier Inc. All rights reserved.|
|Source Title:||Experimental Neurology|
|Appears in Collections:||Staff Publications|
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