Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neulet.2004.06.002
Title: Localization of DJ-1 mRNA in the mouse brain
Authors: Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.Shang, H.
Lang, D.
Jean-Marc, B. 
Kaelin-Lang, A.
Keywords: Basal ganglia, cortex, cerebellum
Central nervous system
DJ-1 gene
In situ hybridization
Motor systems and sensorimotor integration
Parkinson's disease
Issue Date: 9-Sep-2004
Citation: Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A.Shang, H., Lang, D., Jean-Marc, B., Kaelin-Lang, A. (2004-09-09). Localization of DJ-1 mRNA in the mouse brain. Neuroscience Letters 367 (3) : 273-277. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neulet.2004.06.002
Abstract: DJ-1 is mutated in autosomal recessive, early onset Parkinson's disease but the exact localization of the DJ-1 gene product in the mammalian brain is largely unknown. We aimed to evaluate the DJ-1 mRNA expression pattern in the mouse brain. Serial coronal sections of brains of five male and five female adult mice were investigated by using in situ hybridization with a DJ-1 specific 35S-labeled oligonucleotide probe. Hybridized sections were analyzed after exposure to autoradiography films and after coating with a photographic emulsion. DJ-1 was heterogeneously expressed throughout the mouse central nervous system. A high expression of DJ-1 mRNA was detected in neuronal and non-neuronal populations of several structures of the motor system such as the substantia nigra, the red nucleus, the caudate putamen, the globus pallidus, and the deep nuclei of the cerebellum. Furthermore, DJ-1 mRNA was also highly expressed in non-motor structures including the hippocampus, the olfactory bulb, the reticular nucleus of the thalamus, and the piriform cortex. The high expression of DJ-1 mRNA in brain regions involved in motor control is compatible with the occurrence of parkinsonian symptoms after DJ-1 mutations. However, expression in other regions indicates that a dysfunction of DJ-1 may contribute to additional clinical features in patients with a DJ-1 mutation. © 2004 Elsevier Ireland Ltd. All rights reserved.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/130931
ISSN: 03043940
DOI: 10.1016/j.neulet.2004.06.002
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

40
checked on Aug 10, 2018

WEB OF SCIENCETM
Citations

36
checked on Jul 16, 2018

Page view(s)

16
checked on May 17, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.