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|Title:||L-asparaginase induced intracranial haemorrhage in acute lymphoblastic leukemia|
|Keywords:||Acute lymphoblastic leukaemia|
|Citation:||Lim, H.L., Teo, C.P., Wong, K., Kueh, Y.K. (1998-02). L-asparaginase induced intracranial haemorrhage in acute lymphoblastic leukemia. Singapore Medical Journal 39 (2) : 76-78. ScholarBank@NUS Repository.|
|Abstract:||A 20-year-old national serviceman with acute lymphoblastic leukaemia, developed a large left parieto-occipital haemorrhage 7 days after completion of induction chemotherapy. Severe hypofibrinogenemia had been noted while he was receiving L-asparaginase. The haemorrhage could not be attributed to thrombocytopenia, disseminated intravascular coagulopathy, arterio-venous malformation, berry aneurysm or leukaemic infiltration because each of these causes was carefully investigated into and excluded. We conclude that the intracranial haemorrhage was likely L-asparaginase induced, an uncommon but recognised complication associated with L-asparaginase therapy.|
|Source Title:||Singapore Medical Journal|
|Appears in Collections:||Staff Publications|
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