Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/130928
Title: L-asparaginase induced intracranial haemorrhage in acute lymphoblastic leukemia
Authors: Lim, H.L.
Teo, C.P.
Wong, K.
Kueh, Y.K. 
Keywords: Acute lymphoblastic leukaemia
Hypofibrinogenemia
Intracranial haemorrhage
L-asparaginase
Issue Date: Feb-1998
Citation: Lim, H.L., Teo, C.P., Wong, K., Kueh, Y.K. (1998-02). L-asparaginase induced intracranial haemorrhage in acute lymphoblastic leukemia. Singapore Medical Journal 39 (2) : 76-78. ScholarBank@NUS Repository.
Abstract: A 20-year-old national serviceman with acute lymphoblastic leukaemia, developed a large left parieto-occipital haemorrhage 7 days after completion of induction chemotherapy. Severe hypofibrinogenemia had been noted while he was receiving L-asparaginase. The haemorrhage could not be attributed to thrombocytopenia, disseminated intravascular coagulopathy, arterio-venous malformation, berry aneurysm or leukaemic infiltration because each of these causes was carefully investigated into and excluded. We conclude that the intracranial haemorrhage was likely L-asparaginase induced, an uncommon but recognised complication associated with L-asparaginase therapy.
Source Title: Singapore Medical Journal
URI: http://scholarbank.nus.edu.sg/handle/10635/130928
ISSN: 00375675
Appears in Collections:Staff Publications

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