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https://scholarbank.nus.edu.sg/handle/10635/13090
DC Field | Value | |
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dc.title | Fucose upregulates inflammatory immune response in GI tract | |
dc.contributor.author | CHOW WAI LING | |
dc.date.accessioned | 2010-04-08T10:29:50Z | |
dc.date.available | 2010-04-08T10:29:50Z | |
dc.date.issued | 2007-12-17 | |
dc.identifier.citation | CHOW WAI LING (2007-12-17). Fucose upregulates inflammatory immune response in GI tract. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/13090 | |
dc.description.abstract | The immunomodulating effects of fucose on the intestinal epithelial cells (IECs) towards the enteropathogen, Escherichia coli O157: H7 (E. coli O157) and/ or the probiotic Lactobacillus casei Shirota (LcS) were investigated. It was found that the presence of high concentration of free fucose in the gastrointestinal tract may act as a danger signal for IECs; thereby priming both the innate and adaptive immune system, and mucosal integrity. However, when the cells were incubated in fucose with 108 of E. coli O157 or LcS, the magnitude of immune responses observed were reduced. The reverse was seen when the total concentration of the bacteria was doubled (a mixture of 108 of E. coli O157 and 108 LcS) in the presence of fucose. Thus this may suggest that fucose is an immuno-modulator and the molar ratio between the bacteria and free fucose molecules determines the immune responses elicited. (145 words) | |
dc.language.iso | en | |
dc.subject | free fucose, Escherichia coli O157: H7, Lactobacillus casei Shirota, immunodulating effect, immune response, IECs. | |
dc.type | Thesis | |
dc.contributor.department | MICROBIOLOGY | |
dc.contributor.supervisor | LEE YUAN KUN | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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File | Description | Size | Format | Access Settings | Version | |
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Thesis title page and cover page for all sections.pdf | 20 kB | Adobe PDF | OPEN | None | View/Download | |
Acknowledgements, Contents, Summary, List of Fig, Units, Illustrations, Abbreviation, Table.pdf | 75.85 kB | Adobe PDF | OPEN | None | View/Download | |
Chapter1-Introduction.pdf | 28.38 kB | Adobe PDF | OPEN | None | View/Download | |
Chapter3-Materials and Methods.pdf | 146.47 kB | Adobe PDF | OPEN | None | View/Download | |
Chapter4-Experimental Results.pdf | 753.55 kB | Adobe PDF | OPEN | None | View/Download | |
Chapter5-Discussion-Part1.pdf | 40.14 kB | Adobe PDF | OPEN | None | View/Download | |
Chapter5-Discussion-Part2.pdf | 46.11 kB | Adobe PDF | OPEN | None | View/Download | |
Chapter5-Discussion-Part3.pdf | 146.04 kB | Adobe PDF | OPEN | None | View/Download | |
References.pdf | 149.82 kB | Adobe PDF | OPEN | None | View/Download | |
Appendix A-H.pdf | 60.18 kB | Adobe PDF | OPEN | None | View/Download | |
Appendix I.pdf | 644.51 kB | Adobe PDF | OPEN | None | View/Download | |
Appendix J.pdf | 78.01 kB | Adobe PDF | OPEN | None | View/Download | |
Bibliography.pdf | 19.92 kB | Adobe PDF | OPEN | None | View/Download | |
Chapter 2 Lit rev & objectives.pdf | 248.68 kB | Adobe PDF | OPEN | None | View/Download |
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