Please use this identifier to cite or link to this item: https://doi.org/10.1007/s10928-007-9054-4
Title: Weighted target interval stochastic control methods with global optimization and their applications in individualizing therapy
Authors: Ji, S. 
Zeng, Y.
Wu, P.
Lee, E.J.D. 
Keywords: Bayesian estimation
Dosage regimen
Global optimization
Target interval stochastic control
Weighting function
Issue Date: Aug-2007
Citation: Ji, S., Zeng, Y., Wu, P., Lee, E.J.D. (2007-08). Weighted target interval stochastic control methods with global optimization and their applications in individualizing therapy. Journal of Pharmacokinetics and Pharmacodynamics 34 (4) : 433-449. ScholarBank@NUS Repository. https://doi.org/10.1007/s10928-007-9054-4
Abstract: Several improvements on the target interval stochastic control (TISC) method are addressed for individualizing therapy. In particular, a global optimization control strategy is implemented to obtain the optimal dosage regimen, and weighting functions are introduced to balance the drug efficacy and the risk of toxicity. Since general guidance is often lacking in the determination of a weighting function, we introduce a systematic approach, i.e., the standard reference gamble method of medical decision theory, for the determination of the weighting function. The population model for the individualization of theophylline therapy reported by D'Argenio and Katz is applied in this research. The present method of the integration of weighting functions and global optimal strategy offer an effective and safe means to balance the drug efficacy and risk of toxicity. In addition, it also achieves better accuracy than the existing TISC method which uses a local optimal strategy. © 2007 Springer Science+Business Media, LLC.
Source Title: Journal of Pharmacokinetics and Pharmacodynamics
URI: http://scholarbank.nus.edu.sg/handle/10635/130606
ISSN: 1567567X
DOI: 10.1007/s10928-007-9054-4
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

2
checked on Sep 17, 2018

WEB OF SCIENCETM
Citations

2
checked on Aug 29, 2018

Page view(s)

10
checked on May 10, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.