Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/130395
Title: The CCK2 agonist BC264 reverses freezing behavior habituation in PVG hooded rats on repeated exposures to a cat
Authors: Farook, J.M.
McLachlan, C.S. 
Zhu, Y.Z. 
Lee, L. 
Moochhala, S.M. 
Wong, P.T.-H. 
Keywords: Behavior
Freezing
Habituation
PVG hooded and Sprague-Dawley
Rats
Issue Date: 30-Jan-2004
Citation: Farook, J.M., McLachlan, C.S., Zhu, Y.Z., Lee, L., Moochhala, S.M., Wong, P.T.-H. (2004-01-30). The CCK2 agonist BC264 reverses freezing behavior habituation in PVG hooded rats on repeated exposures to a cat. Neuroscience Letters 355 (3) : 205-208. ScholarBank@NUS Repository.
Abstract: Our previous studies (NeuroReport 12 (2001) 2717) showed that PVG hooded and not Sprague-Dawley (SD) rats exhibit remarkable freezing behavior on exposure to a cat in the cat freezing test apparatus. In the present study, we further examined the differences between these two strains of rats in response to repeated daily exposure to a cat in the cat freezing test apparatus. Freezing behavior habituation was observed in both PVG hooded (days 5-7) and SD rats (days 3-7). A selective CCK2 agonist (BC264, 0.3 μg/kg, i.p.) on day 8 reversed habituated freezing behavior and locomotor activity in PVG hooded rats, but not in SD rats. These results suggest that CCK2 receptors mediate habituation to an anxiety-inducing stimulus in PVG hooded rats and further suggest that differential expression of these CCK2 receptors underlies this strain difference. © 2003 Elsevier Ireland Ltd. All rights reserved.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/130395
ISSN: 03043940
Appears in Collections:Staff Publications

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