Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/130394
Title: Strain differences in freezing behavior of PVG hooded and Sprague-Dawley rats: Differential cortical expression of cholecystokinin2 receptors
Authors: Farook, J.M.
Zhu, Y.Z. 
Wang, H. 
Moochhala, S. 
Lee, L. 
Wong, P.T.-H. 
Keywords: Cholecystokinin (CCK)2 receptor expression
Cholecystokinin tetrapeptide
Fear and anxiety
Freezing behavior
LY225910
Rats
Issue Date: 28-Aug-2001
Source: Farook, J.M., Zhu, Y.Z., Wang, H., Moochhala, S., Lee, L., Wong, P.T.-H. (2001-08-28). Strain differences in freezing behavior of PVG hooded and Sprague-Dawley rats: Differential cortical expression of cholecystokinin2 receptors. NeuroReport 12 (12) : 2717-2720. ScholarBank@NUS Repository.
Abstract: PVG hooded, but not Sprague-Dawley (SD), rats showed remarkable freezing behavior on cat exposure. Experiments using cDNA microarray and reverse transcriptase-polymerase chain reaction (RT-PCR) demonstrated that cholecystokinin (CCK)2 receptors were expressed to a greater extent in the PVG hooded rats. A CCK2 antagonist, LY225910, inhibited freezing behavior in the PVG hooded rats while a CCK2 agonist, CCK-4, increased freezing behavior in the SD rats. These results strongly suggest that CCK2 receptors mediate the freezing behavior and the differential expression of these receptors underlie the strain difference in such behavior. © 2001 Lippincott Williams & Wilkins.
Source Title: NeuroReport
URI: http://scholarbank.nus.edu.sg/handle/10635/130394
ISSN: 09594965
Appears in Collections:Staff Publications

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