Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/130378
Title: The use of vigabatrin in infantile spasms in Asian children
Authors: Tay, S.K.H. 
Ong, H.T. 
Low, P.S. 
Keywords: Add-on therapy
Infantile spasms
Monotherapy
Retrospective study
Vigabatrin
Issue Date: Jan-2001
Citation: Tay, S.K.H., Ong, H.T., Low, P.S. (2001-01). The use of vigabatrin in infantile spasms in Asian children. Annals of the Academy of Medicine Singapore 30 (1) : 26-31. ScholarBank@NUS Repository.
Abstract: Background: The use of adrenocorticotrophic hormone (ACTH) and prednisolone in the management of infantile spasms has been well established, but is associated with significant morbidity and cannot be used as long-term medication. Since the introduction of vigabatrin, results have been promising with suggestions currently that it should be used as first-line management of infantile spasms. Aim: The aim of this study was to establish the efficacy, tolerability and problems associated with the use of vigabatrin in Asian children with infantile spasms. Materials and Methods: Eighteen local Asian patients with infantile spasms were given vigabatrin, in 8 as first-line monotherapy and in 10 patients as add-on therapy to pre-existing anti-convulsants. Results: Thirty-nine per cent (7/18) showed 100% suppression of seizures at 2 weeks and 50% (9/18) showing complete suppression of seizures at 4 weeks after starting therapy. There was however, a high relapse rate (56%) in complete responders within the first 6 months of therapy. This was probably due to a lower maintenance dose in the patients, as those who relapsed were on an average dose of 59 mg/kg/day at the time of relapse and responded to a stepped up dose of 83 mg/kg/day. Vigabatrin was well tolerated and only 2 patients developed somnolence and irritability. Conclusion: A dose of at least 70 mg/kg/day may be necessary to achieve adequate control and yet avoid the common adverse affects of vigabatrin.
Source Title: Annals of the Academy of Medicine Singapore
URI: http://scholarbank.nus.edu.sg/handle/10635/130378
ISSN: 03044602
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

21
checked on Nov 2, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.