Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1440-1843.2005.00628.x
Title: Relationship between exhaled nitric oxide and atopy in Asian young adults
Authors: Chng, S.Y. 
Van Bever, H.P. 
Lian, D.
Lee, S.X.
Xu, X.N.
Wang, X.S.
Goh, D.Y.T. 
Keywords: Asian
Asthma
Atopy
Nitric oxide
Rhinitis
Issue Date: Jan-2005
Source: Chng, S.Y., Van Bever, H.P., Lian, D., Lee, S.X., Xu, X.N., Wang, X.S., Goh, D.Y.T. (2005-01). Relationship between exhaled nitric oxide and atopy in Asian young adults. Respirology 10 (1) : 40-45. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1440-1843.2005.00628.x
Abstract: Objectives: The relationship between exhaled nitric oxide and atopy is controversial. The aim of this study was to determine the relationship between exhaled nitric oxide (FENO) and atopy in Asian young adults. Methodology: Subjects were assessed by: (i) the International Study of Asthma and Allergies in Childhood questionnaire to differentiate asthmatic from nonasthmatic and rhinitis from non-rhinitis subjects; (ii) skin prick testing to 10 allergens; and (iii) FENO measurements performed online at a flow rate of 50 mL/s. Results: Complete results were available for 84 subjects. FENO values were highest in atopic asthmatics (n = 34; median FE NO, 59.8 p.p.b.; interquartile range, 30.4-85.5 p.p.b), followed by atopic non-asthmatics (n = 34; median, 38.4 p.p.b.; range, 16.7-49.3 p.p.b), nonatopic asthmatics (n = 5; median, 19.1 p.p.b.; range, 17.9-33.4 p.p.b), and lowest in nonatopic nonasthmatics (n = 11; median, 15.7 p.p.b.; range, 11.5-21.7 p.p.b). FENO values were significantly higher in atopic (n = 68; median, 44.7 p.p.b.; range, 27.3-75.2 p.p.b) compared to nonatopic subjects (n = 16; median, 17.0 p.p.b.; range, 11.7-23.8 p.p.b.; P < 0.0001), regardless of asthma and rhinitis status. FENO levels correlated with the severity of atopy (wheal size) for both asthmatic (r = 0.44, P = 0.005) and nonasthmatic subjects (r = 0.48, P = 0.001). There was no significant difference in FE NO levels between nonatopic asthmatics and nonatopic nonasthmatic subjects (P = 0.25). Conclusions: Increased FENO levels are more reflective of atopy rather than asthma, and increased nitric oxide production may be predominantly a feature of atopy in asthmatics.
Source Title: Respirology
URI: http://scholarbank.nus.edu.sg/handle/10635/130375
ISSN: 13237799
DOI: 10.1111/j.1440-1843.2005.00628.x
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

18
checked on Jan 16, 2018

WEB OF SCIENCETM
Citations

17
checked on Jan 16, 2018

Page view(s)

11
checked on Jan 13, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.