Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/130313
Title: The Effects of Bilateral Vagotomy on Substance P-Like Immunoreactive Nerves in the Cardiac Ganglia of the Monkey (Macaca fascicularis)
Authors: Tay, S.S.W. 
Wong, W.C. 
Keywords: Bilateral vagotomy
Cardiac ganglia
Monkey
Substance P
Issue Date: 1997
Source: Tay, S.S.W., Wong, W.C. (1997). The Effects of Bilateral Vagotomy on Substance P-Like Immunoreactive Nerves in the Cardiac Ganglia of the Monkey (Macaca fascicularis). Journal of Brain Research 38 (1) : 125-132. ScholarBank@NUS Repository.
Abstract: The present study showed that neural degeneration occurred in the cardiac ganglia after bilateral vagotomy. At 1 week after operation, a majority of the substance P-like immunoreactive (SP-IR) nerve fibres were affected and they showed signs of degeneration. SP-IR nerve endings forming the pericellular baskets around seemingly normal neuronal cell bodies were also degenerated. By 2 weeks after operation, numerous macrophage-like cells infiltrated the cardiac ganglia and they engulfed the degenerating SP-IR cellular debris. At 3 months after operation, a few fine SP-IR nerve fibres were detected in the cardiac ganglia, together with a few small solitary SP-IR neurons. At 6-12 months after operation, numerous SP-IR nerve fibres were observed in the cardiac ganglia. Some of the SP-IR nerve endings started to form pericellular baskets around the seemingly normal neuronal cell bodies. It is concluded that there is reinnervation of the heart by SP-IR nerve fibres after surgical interruption to both vagi. However, the origin of these SP-IR nerve fibres and terminals remains unknown.
Source Title: Journal of Brain Research
URI: http://scholarbank.nus.edu.sg/handle/10635/130313
ISSN: 09448160
Appears in Collections:Staff Publications

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