Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neuron.2008.01.019
Title: Setting Clock Speed in Mammals: The CK1ε tau Mutation in Mice Accelerates Circadian Pacemakers by Selectively Destabilizing PERIOD Proteins
Authors: Meng, Q.-J.
Logunova, L.
Maywood, E.S.
Gallego, M.
Lebiecki, J.
Brown, T.M.
Sládek, M.
Semikhodskii, A.S.
Glossop, N.R.J.
Piggins, H.D.
Chesham, J.E.
Bechtold, D.A.
Yoo, S.-H.
Takahashi, J.S.
Virshup, D.M. 
Boot-Handford, R.P.
Hastings, M.H.
Loudon, A.S.I.
Keywords: MOLNEURO
SYSNEURO
Issue Date: 10-Apr-2008
Citation: Meng, Q.-J., Logunova, L., Maywood, E.S., Gallego, M., Lebiecki, J., Brown, T.M., Sládek, M., Semikhodskii, A.S., Glossop, N.R.J., Piggins, H.D., Chesham, J.E., Bechtold, D.A., Yoo, S.-H., Takahashi, J.S., Virshup, D.M., Boot-Handford, R.P., Hastings, M.H., Loudon, A.S.I. (2008-04-10). Setting Clock Speed in Mammals: The CK1ε tau Mutation in Mice Accelerates Circadian Pacemakers by Selectively Destabilizing PERIOD Proteins. Neuron 58 (1) : 78-88. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neuron.2008.01.019
Abstract: The intrinsic period of circadian clocks is their defining adaptive property. To identify the biochemical mechanisms whereby casein kinase1 (CK1) determines circadian period in mammals, we created mouse null and tau mutants of Ck1 epsilon. Circadian period lengthened in CK1ε-/-, whereas CK1εtau/tau shortened circadian period of behavior in vivo and suprachiasmatic nucleus firing rates in vitro, by accelerating PERIOD-dependent molecular feedback loops. CK1εtau/tau also accelerated molecular oscillations in peripheral tissues, revealing its global role in circadian pacemaking. CK1εtau acted by promoting degradation of both nuclear and cytoplasmic PERIOD, but not CRYPTOCHROME, proteins. Together, these whole-animal and biochemical studies explain how tau, as a gain-of-function mutation, acts at a specific circadian phase to promote degradation of PERIOD proteins and thereby accelerate the mammalian clockwork in brain and periphery. © 2008 Elsevier Inc. All rights reserved.
Source Title: Neuron
URI: http://scholarbank.nus.edu.sg/handle/10635/130307
ISSN: 08966273
DOI: 10.1016/j.neuron.2008.01.019
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

199
checked on Jun 16, 2018

WEB OF SCIENCETM
Citations

183
checked on May 30, 2018

Page view(s)

10
checked on May 17, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.