Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/130175
Title: WNT SIGNALLING AT THE MEMBRANE
Authors: ANIRUDH GAUTAM MANNAVA
Keywords: Wnt signalling, GSK3, Disheveled, membrane activation complex, OTK, neuroblast
Issue Date: 14-Jul-2016
Citation: ANIRUDH GAUTAM MANNAVA (2016-07-14). WNT SIGNALLING AT THE MEMBRANE. ScholarBank@NUS Repository.
Abstract: Wnt canonical signaling as studied over the last three decades has been recognized to have a diverse range of functions in development and in disease. Being conserved between invertebrates and vertebrates the signaling molecule was shown to trigger events in a both autocrine and paracrine manner. As a ligand, the Wnt proteins interact with receptors embedded within the plasma membrane causing them to transmit a signal into the cells. The transmission of the signal from outside the membrane into the cell is mediated through a complex formation at the membrane. The work in this thesis is primarily associated with the interactions and functions of GSK3 and Disheveled in the membrane activation complex. Other work included is a contribution to projects pertaining to the receptor tyrosine kinase Otk in non-canonical Wnt signaling and the asymmetric distribution of Disheveled in fly embryonic neuroblasts.
URI: http://scholarbank.nus.edu.sg/handle/10635/130175
Appears in Collections:Master's Theses (Open)

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