Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/130174
Title: COMPARATIVE CHARACTERIZATION OF CELLS FROM DIFFERENT COMPARTMENTS OF THE HUMAN UMBILICAL CORD TISSUE MATRIX FOR STEMNESS PROPERTIES AND CLINICAL UTILITY
Authors: ARJUNAN SUBRAMANIAN
Keywords: Umbilical cord, Mesenchymal stem cells, Best clinical utility, Tumor-associated fibroblasts, Induced pluripotent stem cells, Cell-based therapies
Issue Date: 30-Mar-2016
Citation: ARJUNAN SUBRAMANIAN (2016-03-30). COMPARATIVE CHARACTERIZATION OF CELLS FROM DIFFERENT COMPARTMENTS OF THE HUMAN UMBILICAL CORD TISSUE MATRIX FOR STEMNESS PROPERTIES AND CLINICAL UTILITY. ScholarBank@NUS Repository.
Abstract: The various microanatomical compartments of the umbilical cord (UC) tissue matrix are rich sources of mesenchymal stem cells (MSCs). However, there is no rigorous comparative characterization of cells between these compartments to identify which compartment generates MSCs with the best clinical utility for cell-based therapies. The results of present study showed that MSCs from the Wharton’s Jelly (WJ) compartment offer the best clinical utility as their derivation is quick and easy to standardize; furthermore, they are rich in stemness characteristics, safe as they do not transform into tumor-associated fibroblasts and reprogrammable into iPSCs. The present thesis thus brought to light the many advantages of Wharton’s jelly stem cells (hWJSCs) compared to other MSCs within the UC and conventional bone marrow MSCs. Therefore, both the naïve hWJSCs and the hWJSC-iPSCs, would be the best cell types for future clinical and research application compared to MSCs from other compartments within the UC.
URI: http://scholarbank.nus.edu.sg/handle/10635/130174
Appears in Collections:Ph.D Theses (Open)

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