Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/12999
Title: Identification and characterization of a novel heart- reactive autoantibody in systemic lupus erythematosus: Possible serological marker for early myocardial dysfunction
Authors: XU QIAN
Keywords: lupus; autoantibody; cardiac troponin I; echocardiography; interleukin 18; single nucleotide polymorphism
Issue Date: 22-Nov-2007
Source: XU QIAN (2007-11-22). Identification and characterization of a novel heart- reactive autoantibody in systemic lupus erythematosus: Possible serological marker for early myocardial dysfunction. ScholarBank@NUS Repository.
Abstract: In the study, a 29-kDa heart reactive autoantibody was identified in lupus sera by immunoblots, and characterized as anti-cTnI antibody by 2-D electrophoresis and mass spectrophotometry. The prevalence of this antibody was found to be 12% in a cohort of 109 lupus patients. Color Doppler echocardiography with measurements of strain and strain rates were performed to evaluate cardiac function. Anti-cTnI positivity was found to correlate with reduced early diastolic longitudinal strain rates. Two single nucleotide polymorphisms at position -607 and -137 of the interleukin 18 promoter gene were also studied. The frequency of SNP-607/CC was found to be significantly higher in Chinese SLE patients compared to the control individuals. A significant decrease of SNP-607/AC was also observed in SLE patients compared to the controls. SLE patients have significantly higher circulating IL-18 protein levels than normal controls. And patients who have anti-cTnI antibody may have higher circulating IL-18 proteins.
URI: http://scholarbank.nus.edu.sg/handle/10635/12999
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