Please use this identifier to cite or link to this item: https://doi.org/10.1084/jem.20090805
Title: Mast cell-derived particles deliver peripheral signals to remote lymph nodes
Authors: Kunder, C.A.
St. John, A.L.
Li, G.
Leong, K.W.
Berwin, B.
Staats, H.F.
Abraham, S.N. 
Issue Date: 26-Oct-2009
Citation: Kunder, C.A., St. John, A.L., Li, G., Leong, K.W., Berwin, B., Staats, H.F., Abraham, S.N. (2009-10-26). Mast cell-derived particles deliver peripheral signals to remote lymph nodes. Journal of Experimental Medicine 206 (11) : 2455-2467. ScholarBank@NUS Repository. https://doi.org/10.1084/jem.20090805
Abstract: During infection, signals from the periphery are known to reach draining lymph nodes (DLNs), but how these molecules, such as inflammatory cytokines, traverse the significant distances involved without dilution or degradation remains unclear. We show that peripheral mast cells, upon activation, release stable submicrometer heparin-based particles containing tumor necrosis factor and other proteins. These complexes enter lymphatic vessels and rapidly traffic to the DLNs. This physiological drug delivery system facilitates communication between peripheral sites of inflammation and remote secondary lymphoid tissues. © 2009 Kunder et al.
Source Title: Journal of Experimental Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/129911
ISSN: 00221007
DOI: 10.1084/jem.20090805
Appears in Collections:Staff Publications

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