Please use this identifier to cite or link to this item:
|Title:||Mast cell-derived particles deliver peripheral signals to remote lymph nodes|
St. John, A.L.
|Citation:||Kunder, C.A., St. John, A.L., Li, G., Leong, K.W., Berwin, B., Staats, H.F., Abraham, S.N. (2009-10-26). Mast cell-derived particles deliver peripheral signals to remote lymph nodes. Journal of Experimental Medicine 206 (11) : 2455-2467. ScholarBank@NUS Repository. https://doi.org/10.1084/jem.20090805|
|Abstract:||During infection, signals from the periphery are known to reach draining lymph nodes (DLNs), but how these molecules, such as inflammatory cytokines, traverse the significant distances involved without dilution or degradation remains unclear. We show that peripheral mast cells, upon activation, release stable submicrometer heparin-based particles containing tumor necrosis factor and other proteins. These complexes enter lymphatic vessels and rapidly traffic to the DLNs. This physiological drug delivery system facilitates communication between peripheral sites of inflammation and remote secondary lymphoid tissues. © 2009 Kunder et al.|
|Source Title:||Journal of Experimental Medicine|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on May 21, 2018
WEB OF SCIENCETM
checked on Apr 24, 2018
checked on May 17, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.