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Title: A comparison of the relative growth velocities with budesonide and fluticasone propionate in children with asthma
Authors: Ferguson, A.C.
Van Bever, H.P. 
Teper, A.M.
Lasytsya, O.
Goldfrad, C.H.
Whitehead, P.J.
Keywords: Asthma
Fluticasone propionate
Issue Date: Jan-2007
Citation: Ferguson, A.C., Van Bever, H.P., Teper, A.M., Lasytsya, O., Goldfrad, C.H., Whitehead, P.J. (2007-01). A comparison of the relative growth velocities with budesonide and fluticasone propionate in children with asthma. Respiratory Medicine 101 (1) : 118-129. ScholarBank@NUS Repository.
Abstract: There have been no previous large, well-designed direct comparisons of the effects of fluticasone propionate (FP) and budesonide (BUD) on growth in children. This randomised, double-blind study compared the effects on growth of FP and BUD in children aged 6-9 years with persistent asthma. Following a 6-month run-in period (without inhaled corticosteroids), patients with normal growth velocity were randomised to 12 months' treatment with FP 100 μg bd (n = 114) or BUD 200 μg bd (n = 119). Growth velocity was determined by stadiometric height measurement. Lung function, asthma symptoms and use of relief medication were also assessed. Annualised mean growth velocity during run-in was comparable in the two groups (FP: 5.9 cm/yr; BUD: 6.0 cm/yr). During the treatment period, adjusted mean growth velocity was significantly higher in the FP than the BUD group (5.5 cm/yr vs 4.6 cm/yr; P < 0.001). Asthma control improved similarly in both treatment groups. Bone mineral density and overnight urinary cortisol:creatinine ratios were similar in the two groups. Drug-related adverse events were reported among 3% of FP-treated children, compared with 2% for BUD. In conclusion, this study demonstrates that FP for childhood asthma has significantly less impact on childhood growth velocity than a therapeutically equivalent dose of BUD. © 2006 Elsevier Ltd. All rights reserved.
Source Title: Respiratory Medicine
ISSN: 09546111
DOI: 10.1016/j.rmed.2006.04.009
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