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|Title:||Adult neural stem cells and their niches: Developmental and therapeutic implications|
Pluripotent stem cells
|Source:||Taupin, P. (2007). Adult neural stem cells and their niches: Developmental and therapeutic implications. Journal of Stem Cells 2 (1) : 41-46. ScholarBank@NUS Repository.|
|Abstract:||Contrary to the long-held dogma, neurogenesis occurs in the adult brain and neural stem cells (NSCs) reside in the adult central nervous system (CNS). This suggests that the CNS has the potential to self-repair. In support of this contention, neurogenesis is modulated in the adult brain, new neuronal cells are generated at sites of degeneration and injuries, after transplantation adult-derived neural progenitor and stem cells adopt the fate of the tissue, and adult stem cells may have the potential to differentiate into other lineages. Niches are microenvironments that control stem cells activity. The therapeutic potential of stem cells, and particularly adult NSCs, lies therefore in the interaction between stem cells and their niches. Neurogenic niches have been identified in the adult brain. Unraveling the interactions between NSCs and their niches will contribute to our understanding of the developmental potential of adult stem cells, and to bring adult NSC research to therapy. © 2007 Nova Science Publishers, Inc.|
|Source Title:||Journal of Stem Cells|
|Appears in Collections:||Staff Publications|
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