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Title: Cyclooxygenase-2 expression in Warthin's tumour
Authors: Loy, A.H.C. 
Putti, T.C.
Tan, L.K.S. 
Keywords: Cyclooxygenase-2
Warthin's Tumour
Issue Date: Jul-2005
Citation: Loy, A.H.C., Putti, T.C., Tan, L.K.S. (2005-07). Cyclooxygenase-2 expression in Warthin's tumour. Journal of Laryngology and Otology 119 (7) : 515-518. ScholarBank@NUS Repository.
Abstract: Objectives: To determine whether cyclooxygenase-2 (COX-2) is overexpressed in Warthin's tumours, and to characterize its pattern of expression. Methods: Twenty-one paraffin-embedded Warthin's tumour specimens were analysed by immunohistochemical staining for expression of human COX-2. Semi-quantitative analysis of the staining was performed. Results: In all of the specimens, we found that there was overexpression of COX-2 within the epithelial component of the tumours, with no expression in the lymphoid components. There was also overexpression of COX-2 in the salivary duct system of normal parotid tissue. Conclusions: Our results suggest that COX-2 is up-regulated in the epithelial component of Warthin's tumours. Our findings support the hypothesis that Warthin's tumours originate from heterotopic ductal epithelial cells of the parotid gland. The role of COX-2 expression in the pathogenesis of Warthin's tumours remains to be determined.
Source Title: Journal of Laryngology and Otology
ISSN: 00222151
DOI: 10.1258/0022215054352117
Appears in Collections:Staff Publications

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