Please use this identifier to cite or link to this item: https://doi.org/10.1002/ijc.10925
Title: Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase
Authors: Meyer, T.
Xu, L.
Chang, J.
Lui, E.T. 
Craven, R.J.
Cance, W.G.
Keywords: Breast cancer
Cell cycle
Rak
Src
Tyrosine kinase
Issue Date: 20-Mar-2003
Source: Meyer, T., Xu, L., Chang, J., Lui, E.T., Craven, R.J., Cance, W.G. (2003-03-20). Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase. International Journal of Cancer 104 (2) : 139-146. ScholarBank@NUS Repository. https://doi.org/10.1002/ijc.10925
Abstract: Rak is a 54 kDa protein tyrosine kinase originally isolated from breast cancer cells and expressed in epithelial cells. It resembles the protooncogene Src structurally but lacks an amino-terminal myristylation site and localizes to the nuclear and perinuclear regions of the cell. We report here that expression of Rak in 2 different breast cancer cell lines inhibits growth and causes G1 arrest of the cell cycle. This growth inhibition is kinase-dependent but does not require the Rak SH2 or SH3 domain. Rak also binds to the pRb tumor-suppressor protein but inhibits growth even in cells that lack pRb. These results suggest that Rak regulates cell growth by phosphorylating perinuclear proteins and has a function that is distinct from the Src-related kinase family. © 2002 Wiley-Liss, Inc.
Source Title: International Journal of Cancer
URI: http://scholarbank.nus.edu.sg/handle/10635/129535
ISSN: 00207136
DOI: 10.1002/ijc.10925
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