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Please use this identifier to cite or link to this item: https://doi.org/10.1021/np900336f
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dc.titleCarteriosulfonic acids A-C, GSK-3β inhibitors from a Carteriospongia sp.
dc.contributor.authorMcCulloch, M.W.B.
dc.contributor.authorBugni, T.S.
dc.contributor.authorConcepcion, G.P.
dc.contributor.authorCoombs, G.S.
dc.contributor.authorHarper, M.K.
dc.contributor.authorKaur, S.
dc.contributor.authorMangalindan, G.C.
dc.contributor.authorMutizwa, M.M.
dc.contributor.authorVeltri, C.A.
dc.contributor.authorVirshup, D.M.
dc.contributor.authorIreland, C.M.
dc.date.accessioned2016-11-08T08:22:56Z
dc.date.available2016-11-08T08:22:56Z
dc.date.issued2009-09-25
dc.identifier.citationMcCulloch, M.W.B., Bugni, T.S., Concepcion, G.P., Coombs, G.S., Harper, M.K., Kaur, S., Mangalindan, G.C., Mutizwa, M.M., Veltri, C.A., Virshup, D.M., Ireland, C.M. (2009-09-25). Carteriosulfonic acids A-C, GSK-3β inhibitors from a Carteriospongia sp.. Journal of Natural Products 72 (9) : 1651-1656. ScholarBank@NUS Repository. https://doi.org/10.1021/np900336f
dc.identifier.issn01633864
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/129468
dc.description.abstractModulators of Wnt signaling have therapeutic potential in a number of human diseases. A fractionated library from marine invertebrates was screened in a luciferase assay designed to identify modulators of Wnt signaling. A fraction from a Carteriospongia sp. sponge activated Wnt signaling and was subsequently shown to inhibit GSK-3β, which inhibits Wnt signaling through phosphorylation of β-catenin. Three novel natural products, carteriosulfonic acids A (1), B (2), and C (3), were identified as active constituents. The carteriosulfonic acids contain unprecedented 4,6,7,9-tetrahydroxylated decanoic acid subunits. Their structures were elucidated through analysis of NMR data and a detailed analysis of pseudo MS3 spectra. © 2009 American Chemical Society and American Society of Pharmacognosy.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/np900336f
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1021/np900336f
dc.description.sourcetitleJournal of Natural Products
dc.description.volume72
dc.description.issue9
dc.description.page1651-1656
dc.description.codenJNPRD
dc.identifier.isiut000270855600018
Appears in Collections:Staff Publications

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