Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/129173
Title: Cation transport across lymphocyte plasma membranes in euthyroid and thyrotoxic men with and without hypokalaemic periodic paralysis
Authors: Oh, V.M.S. 
Taylor, E.A.
Yeo, S.-H.
Lee, K.-O. 
Keywords: Cardiac glycoside receptors
Hypokalaemic periodic paralysis
Lymphocyte
Sodium-potassium-adenosine triphosphatase
Sodium-potassium-chloride co-transport
Thyrotoxicosis
Issue Date: 1990
Source: Oh, V.M.S.,Taylor, E.A.,Yeo, S.-H.,Lee, K.-O. (1990). Cation transport across lymphocyte plasma membranes in euthyroid and thyrotoxic men with and without hypokalaemic periodic paralysis. Clinical Science 78 (2) : 199-206. ScholarBank@NUS Repository.
Abstract: 1. To study potassium transport in hypokalaemic periodic paralysis in a model of striated muscle cells, we measured specific [3H] ouabain binding (the number of sodium-potassium pumps), sodium-potasium-pump-mediated (ouabain-senstive) 86Rb influx and sodium-potassium-pump-independent (ouabain-resistant) 86Rb+ influx in lymphocytes in vitro. 2. The subjects comprised euthyroid and thyrotoxic men with hypokalaemic periodic paralysis between attacks, men with uncomplicated thyrotoxicosis, and healthy men matched for age and weight. 3. Thyrotoxic patients, both with and without periodic paralysis, had significantly more lymphocyte sodium-potassium pumps than normal, and a significantly greater sodium-potasium-pump-mediated 86Rb+ influx. Antithyroid treatment corrected this defect in patients with thyrotoxic periodic paralysis. Euthyroid patients with cryptogenic periodic paralysis had significantly increased sodium-potassium-pump-mediated 86Rb+ influx, but a normal number of sodium-potassium pumps. 4. Only untreated thyrotoxic and euthyroid patients with periodic paralysis showed a significant increase in sodium-potassium-pump-independent 86Rb+ influx (5.2 ± 2.8 and 4.5 ± 1.8 respectively, vs control 2.8 ± 1.0 pmol h-1 10-6 cells; mean ± sd; P
Source Title: Clinical Science
URI: http://scholarbank.nus.edu.sg/handle/10635/129173
ISSN: 01435221
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

10
checked on Jan 13, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.