Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/129143
Title: CHITOSAN AND ITS DERIVATIVE NANOPARTICLES FOR DRUG DELIVERY INTO BRAIN USING INTRANASAL ADMINISTRATION: PREPARATION, CHARACTERIZATION, IN VITRO AND IN VIVO EVALUATION
Authors: LIU SHANSHAN
Keywords: Chitosan, nanoparticles, carbamazepine, scutellarin, intranasal, brain targeting
Issue Date: 22-Jan-2016
Source: LIU SHANSHAN (2016-01-22). CHITOSAN AND ITS DERIVATIVE NANOPARTICLES FOR DRUG DELIVERY INTO BRAIN USING INTRANASAL ADMINISTRATION: PREPARATION, CHARACTERIZATION, IN VITRO AND IN VIVO EVALUATION. ScholarBank@NUS Repository.
Abstract: The presence of blood-brain barrier restricts the entry of most drugs for the treatment of central nervous system diseases. To overcome this problem and enhance the drug permeability into brain, we propose using carboxymethyl chitosan and chitosan nanoparticles as carriers to deliver drugs intra-nasally to enhance the brain drug concentration and treatment efficacy of certain drugs. As a result, using chitosan could result in a smaller particle size, higher drug loading, more stable in vitro release and better brain absorption. Moreover, intranasal administration had a significant trend of brain-targeted when compared to oral administration,indicated that it had a certain feasibility to explore a brain-targeted nasal delivery system modified by chitosan for the treatment of central nervous system diseases.
URI: http://scholarbank.nus.edu.sg/handle/10635/129143
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