Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/129141
Title: CREATION OF TRANSPORT PATHWAYS ACROSS SKIN BY MICRONEEDLES FOR DRUG DELIVERY
Authors: LI HAIRUI
Keywords: Microneedles, drug delivery, antimicrobial, copper peptide, dry patch, copper toxicity
Issue Date: 19-Jan-2016
Citation: LI HAIRUI (2016-01-19). CREATION OF TRANSPORT PATHWAYS ACROSS SKIN BY MICRONEEDLES FOR DRUG DELIVERY. ScholarBank@NUS Repository.
Abstract: Increasing studies have been carried out on microneedles for transdermal drug delivery, mostly focused on fabrication techniques and general application of microneedles. However, there are still a number of issues that limit the effective and safe use of microneedles. In this thesis, a tripeptide copper complex (GHK-Cu) was used to study the factors influencing microneedle-mediated transdermal drug delivery efficacy with the aim to explore the underlying mechanisms of enhanced delivery by microneedles. Skin toxicity potential of GHK-Cu was further studied and compared with two other copper compounds, copper chloride and copper acetate by an in vitro skin irritation test with multiple biomarkers used. To minimize the risk of infections, antimicrobial microneedles were prepared by coating the needles with novel quaternary ammonium silane antimicrobial copolymers. Lastly, an adhesive-free and solvent-free skin patch, namely dry patch, for the percutaneous delivery of lidocaine was fabricated to be applied together with microneedles.
URI: http://scholarbank.nus.edu.sg/handle/10635/129141
Appears in Collections:Ph.D Theses (Open)

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