Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/129123
Title: DEVELOPMENT OF MICRONEEDLES ON FLEXIBLE SKIN PATCH WITH FUNCTIONAL COMPONENTS FOR TRANSDERMAL DRUG DELIVERY APPLICATIONS
Authors: WANG HAO
Keywords: microneedle, flexible skin patch, transdermal drug delivery, triboelectric energy harvester, microfluidic control system, drawing lithography
Issue Date: 19-Jan-2016
Source: WANG HAO (2016-01-19). DEVELOPMENT OF MICRONEEDLES ON FLEXIBLE SKIN PATCH WITH FUNCTIONAL COMPONENTS FOR TRANSDERMAL DRUG DELIVERY APPLICATIONS. ScholarBank@NUS Repository.
Abstract: This work aims developing different kinds of microneedles with various configurations and functions for transdermal drug delivery applications. Here we developed a very unique technology called drawing lithography for the assembly of SU-8 and maltose sharp tips at the final step of the fabrication process, which is compatible with most of the conventional thin film technology and allows us to explore more possibilities about integrating other functional components and sophisticated system with microneedles. A novel Carbon Nanotubes (CNTs) filter, which can be used for selective transport of bio-molecules, is integrated within the microneedles. We also integrated microneedles with a complex system to make a self-powered, flexible microneedle skin patch which is suitable for self-administrated insulin delivery. In order to have a precise dose control required by insulin delivery, a delivery volume sensor based on triboelectric mechanism is designed and optimized. For powering other functional components to be integrated in the future, a low cost power source, which leverages the stacked layer triboelectric energy harvester design, is characterized to achieve 33μw output power. Moreover, in order to make the device truly wearable, dry adhesive technique is further applied to make the device able to be attached onto any part of the body.
URI: http://scholarbank.nus.edu.sg/handle/10635/129123
Appears in Collections:Ph.D Theses (Open)

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