Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/129114
Title: PROTECTIVE EFFECT OF FTO ABLATION AGAINST PALMITIC ACID-INDUCED LIPOTOXICITY IN NASH
Authors: LIM ANDREA
Keywords: Non-alcoholic steatohepatitis (NASH), Fat and obesity associated (FTO) gene, Obesity, Lipotoxicity, Palmitic acid
Issue Date: 8-Jun-2016
Citation: LIM ANDREA (2016-06-08). PROTECTIVE EFFECT OF FTO ABLATION AGAINST PALMITIC ACID-INDUCED LIPOTOXICITY IN NASH. ScholarBank@NUS Repository.
Abstract: Genome-wide association studies (GWAS) have identified noncoding polymorphisms in the fat mass and obesity-associated (FTO) gene to be strongly associated with effects on food intake and adiposity in humans. However, its causative role in obesity related metabolic disorders remain unclear. Non-alcoholic steatohepatitis (NASH) is a common comorbidity associated with obesity, and is characterized with excess fat accumulation and increased lipotoxicity in hepatocytes. In this work, investigations into the role of FTO in NASH were undertaken. Hepatic FTO expression is significantly increased in both NASH patients and rodent model of NASH. Furthermore, genetic silencing of FTO protects against palmitate-induced oxidative stress, mitochondrial dysfunction, ER-stress, and apoptosis in vitro. Taken together, these results strongly suggest that the upregulation of FTO may lead to increased liver damage in NASH, and its pharmacological modulation may represent a novel strategy to counter hepatic lipotoxicity.
URI: http://scholarbank.nus.edu.sg/handle/10635/129114
Appears in Collections:Master's Theses (Open)

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