Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0021-9673(96)00617-6
Title: Application of liquid chromatography-atmospheric pressure ionization mass spectrometry in natural product analysis. Evaluation and optimization of electrospray and heated nebulizer interfaces
Authors: Zhou, S. 
Hamburger, M.
Keywords: atmosphere pressure chemical ionization
detection, LC
electrospray ionization
interfaces
nebulizing interface
Issue Date: 6-Dec-1996
Citation: Zhou, S., Hamburger, M. (1996-12-06). Application of liquid chromatography-atmospheric pressure ionization mass spectrometry in natural product analysis. Evaluation and optimization of electrospray and heated nebulizer interfaces. Journal of Chromatography A 755 (2) : 189-204. ScholarBank@NUS Repository. https://doi.org/10.1016/S0021-9673(96)00617-6
Abstract: A representative set of 46 secondary metabolites of plant and microbial origin was examined with electrospray and atmospheric pressure chemical ionization MS in both positive and negative ion mode, in order to evaluate the applicability of atmospheric pressure ionization LC-MS as a tool for rapid identification and dereplication of bioactive compounds in the drug screening process. MS characteristics of different compound classes were determined on the basis of quasi-molecular ion and other adduct ion responses observed with the two LC-MS interfaces. Interface parameters and LC mobile phase composition were optimized and an analytical protocol applicable to a wide range of secondary metabolites is proposed.
Source Title: Journal of Chromatography A
URI: http://scholarbank.nus.edu.sg/handle/10635/129084
ISSN: 00219673
DOI: 10.1016/S0021-9673(96)00617-6
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