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Title: Natural killer cell engineering for cellular therapy of cancer
Authors: Shook, D.R.
Campana, D. 
Keywords: Cell therapy
Chimeric receptors
Natural killer cells
Issue Date: Dec-2011
Citation: Shook, D.R., Campana, D. (2011-12). Natural killer cell engineering for cellular therapy of cancer. Tissue Antigens 78 (6) : 409-415. ScholarBank@NUS Repository.
Abstract: Natural killer (NK) cells can kill transformed cells and represent a promising tool for the treatment of cancer. Their function is governed by a balance of stimulatory and inhibitory signals triggered by surface receptors. Advances in NK cell therapy require the development of dependable methods for obtaining an adequate number of effector cells; additional activation or genetic modification may further increase their anticancer capacity. A method for NK cell expansion used in our laboratory relies on a genetically modified form of the K562 myeloid leukemia cell line, engineered to express a membrane-bound form of interleukin-15 and the ligand for the costimulatory molecule 4-1BB (CD137). Expanded NK cells can be transduced with genes encoding chimeric antigen receptors that stimulate tumor cell-specific cytotoxicity. These methods for NK cell expansion and genetic modification have been adapted to large-scale, clinical-grade, Current Good Manufacturing Practice conditions and support two active clinical trials. Summarized are current efforts for NK cell immunotherapy for cancer and future perspectives. © 2011 John Wiley & Sons A/S.
Source Title: Tissue Antigens
ISSN: 00012815
DOI: 10.1111/j.1399-0039.2011.01796.x
Appears in Collections:Staff Publications

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