Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.toxicon.2013.05.010
Title: Synthesis and characterization of amino acid deletion analogs of κ-hefutoxin 1, a scorpion toxin on potassium channels
Authors: Peigneur, S.
Yamaguchi, Y.
Goto, H.
Srinivasan, K.N.
Gopalakrishnakone, P. 
Tytgat, J.
Sato, K.
Keywords: κ-Hefutoxin 1
Amino acid deletion
Scorpion toxin
Subtype selectivity
Synthetic analogs
Voltage-gated potassium channel
Issue Date: 1-Sep-2013
Citation: Peigneur, S., Yamaguchi, Y., Goto, H., Srinivasan, K.N., Gopalakrishnakone, P., Tytgat, J., Sato, K. (2013-09-01). Synthesis and characterization of amino acid deletion analogs of κ-hefutoxin 1, a scorpion toxin on potassium channels. Toxicon 71 : 25-30. ScholarBank@NUS Repository. https://doi.org/10.1016/j.toxicon.2013.05.010
Abstract: Nine analogs of scorpion toxin peptide κ-hefutoxin 1 were synthesized by stepwise deletion of its amino acid residues. Disulfide bond pairings of the synthetic analogs were confirmed by enzymatic digestion followed by MALDI-TOF-MS measurements. Functional characterization shows that analogs in which N-terminal residues were deleted retained biological activity, whereas deletion of middle part residues resulted in loss of activity. Furthermore, κ-hefutoxin 1 and analogs were subjected to a screening on voltage-gated potassium channels in order to determine their subtype selectivity. It is shown that κ-hefutoxin 1 is suitable as template for peptidomimetics in order to design small peptide-based therapeutic compounds. © 2013 Elsevier Ltd.
Source Title: Toxicon
URI: http://scholarbank.nus.edu.sg/handle/10635/128954
ISSN: 00410101
DOI: 10.1016/j.toxicon.2013.05.010
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