Please use this identifier to cite or link to this item:
|Title:||Co-localization of L-type voltage dependent calcium channel alpha 1D subunit (Cav1.3) and calbindin (CB) in the mouse central nervous system|
Central nervous system
|Source:||Xu, J.H., Yang, Z.B., Wang, H., Tang, F.-R. (2014-02-21). Co-localization of L-type voltage dependent calcium channel alpha 1D subunit (Cav1.3) and calbindin (CB) in the mouse central nervous system. Neuroscience Letters 561 : 80-85. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neulet.2013.12.057|
|Abstract:||Previous study has shown that the co-localization of calbindin (CB) with L-type voltage dependent Ca2+ channel (VDCC) alpha 1C subunit (Cav1.2) in the rat insulinoma 1046-38 (RIN) beta cells may play an important regulatory role in Ca2+ influx and exocytosis of insulin granules. In the present study, L-type voltage dependent Ca2+ channel (VDCC) and calbindin (CB) were demonstrated in different regions of the mouse central nervous system (CNS). Double labeling immunofluorescence staining showed a co-localization of Cav1.3 and CB. The co-localization of Cav1.3 and CB in certain brain regions such as the hippocampus suggests their important roles in neuroplasticity. The relative high percentages of co-localization of Cav1.3 with CB in the laminae II of the dorsal horn of the spinal cord indicate that the regulation mechanism of nociceptive transmission may be related with both VDCC and Ca2+ binding protein. © 2013 Elsevier Ireland Ltd.|
|Source Title:||Neuroscience Letters|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 15, 2018
WEB OF SCIENCETM
checked on Jan 30, 2018
checked on Feb 19, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.